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Publications

2023

Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis

Venkatakrishnan V, Ghode A, Tulsian NK, Anand GS. 

Front Mol Biosci. 2023;10:1202268.

Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein

Sacerdoti M, Gross LZF, Riley AM, et al.

Sci Signal. 2023;16(789):eadd3184.

A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes.

Zuzic L, Marzinek JK, Anand GS, Warwicker J, Bond PJ.

Elife. 2023;12:e82447.

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics.

Braet SM, Buckley TSC, Venkatakrishnan V, Dam KA, Bjorkman PJ, Anand GS.

Elife. 2023;12:e82584

SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade

Samsudin F, Raghuvamsi P, Petruk G, et al.

J Mol Cell Biol. 2023;14(9):mjac058.

2022

Ligand-induced shifts in conformational ensembles that describe transcriptional activation

Khan SH, Braet SM, Koehler SJ, Elacqua E, Anand GS, Okafor CD.

Elife. 2022;11:e80140.

The ganglioside GM1a functions as a coreceptor/attachment factor for dengue virus during infection

Tantirimudalige SN, Raghuvamsi PV, Sharma KK, Wei Bao JC, Anand GS, Wohland T. 

J Biol Chem. 2022;298(11):102570.

Hyperosmotic Stress Allosterically Reconfigures Betaine Binding Pocket in BetP. 

Tantirimudalige S, Buckley TSC, Chandramohan A, Richter RM, Ziegler C, Anand GS.

J Mol Biol. 2022;434(17):167747.

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein. Structure

Zuzic L, Samsudin F, Shivgan AT, et al.

Structure. 2022;30(8):1062-1074.e4

 Identification of putative binding interface of PI(3,5)P2 lipid on rice black-streaked dwarf virus (RBSDV) P10 protein. 

Liu H, Peck XY, Choong YK, et al.

Virology. 2022;570:81-95.

2021

Development of Phosphodiesterase-Protein-Kinase Complexes as Novel Targets for Discovery of Inhibitors with Enhanced Specificity

Tulsian NK, Sin VJ, Koh HL, Anand GS. 

Int J Mol Sci. 2021;22(10):5242. 

Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics

Lim XX, Shu B, Zhang S, et al.

Cell. 2021;184(25):6067-6080.e13.

SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

Raghuvamsi PV, Tulsian NK, Samsudin F, Qian X, Purushotorman K, Yue G, Kozma MM, Hwa WY, Lescar J, Bond PJ, MacAry PA, Anand GS.

eLife 2021 Feb 8;10:e63646. 

Dengue virus strain 2 capsid protein switches the annealing pathway and reduces intrinsic dynamics of the conserved 5′ untranslated region

Yong XE, Raghuvamsi PV, Anand GS, Wohland T, Sharma KK.

RNA Biol. 2021 Jan 7:1-14. 

2020

An NMR based phosphodiesterase assay

Akimoto M , Yu T , Moleschi K , Van K , Anand GS , Melacini G.

Chem Commun (Camb). 2020 Jul 25;56(58):8091-8094.

Synergistic Allostery in Multiligand-Protein Interactions

Ghode A, Gross LZF, Tee WV, Guarnera E, Berezovsky IN, Biondi RM, Anand GS.

Biophys J. 2020 Nov 3;119(9):1833-1848.

Botanical Medicine and Natural Products Used for Erectile Dysfunction

Sin VJ, Anand GS, Koh HL.

Sex Med Rev. 2020 Dec 1:S2050-0521(20)30114-1. 

Two-Component Signaling: An Archetype System That Can Function Noncanonically

Kenney LJ, Anand GS.

EcoSal Plus. 2020 Jan;9(1):10.1128/ecosalplus.

Adenylate control in cAMP signaling: implications for adaptation in signalosomes

Tulsian NK, Ghode A, Anand GS.

Biochem J. 2020 Aug 28;477(16):2981-2998. 

Structural Basis of Oligomerization of N-Terminal Domain of Spider Aciniform Silk Protein

Chakraborty R, Fan JS, Lai CC, Raghuvamsi PV, Chee PX, Anand GS, Yang D. 

Int J Mol Sci. 2020 Jun 23;21(12):4466.

2019

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. 

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602.

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb

Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable J, Steckler C, Park I, Brock A, Lu X, Pandey R, Chandramohan A, Anand GS, Nirudodhi SN, Sperry JB, Rouse JC, Carroll JA, Rand KD, Leurs U, Weis DD, Al-Naqshabandi MA, Hageman TS, Deredge D, Wintrode PL, Papanastasiou M, Lambris JD, Li S, Urata S.

Anal Chem. 2019 Jun 4;91(11):7336-7345.

Uncovering metastability and disassembly hotspots in whole viral particles

Ramesh R, Lim XX, Raghuvamsi PV, Wu C, Wong SM, Anand GS. 

Prog Biophys Mol Biol. 2019 May;143:5-12.

Infectivity of Dengue Virus Serotypes 1 and 2 Is Correlated with E-Protein Intrinsic Dynamics but Not to Envelope Conformations

Sharma KK, Lim XX, Tantirimudalige SN, Gupta A, Marzinek JK, Holdbrook D, Lim XYE, Bond PJ, Anand GS, Wohland T.

Structure. 2019 Apr 2;27(4):618-630. 

HDX-MS reveals orthosteric and allosteric changes in apolipoprotein-D structural dynamics upon binding of progesterone

Kielkopf CS, Ghosh M, Anand GS, Brown SHJ.

Protein Sci. 2019 Feb;28(2):365-374.

Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody

Wirawan M, Fibriansah G, Marzinek JK, Lim XX, Ng TS, Sim AYL, Zhang Q, Kostyuchenko VA, Shi J, Smith SA, Verma CS, Anand G, Crowe JE Jr, Bond PJ, Lok SM.

Structure. 2019 Feb 5;27(2):253-267.

Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices

Ghosh M, Wang LC, Huber RG, Gao Y, Morgan LK, Tulsian NK, Bond PJ, Kenney LJ, Anand GS.

Structure. 2019 Feb 5;27(2):302-314.

2018

SUMO Suppresses the Activity of the Jasmonic Acid Receptor CORONATINE INSENSITIVE1

Srivastava AK, Orosa B, Singh P, Cummins I, Walsh C, Zhang C, Grant M, Roberts MR, Anand GS, Fitches E, Sadanandom A.

Plant Cell. 2018 Sep;30(9):2099-2115. 

Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice

Kao C, Chandna R, Ghode A, Dsouza C, Chen M, Larsson A, Lim SH, Wang M, Cao Z, Zhu Y, Anand GS.

EBioMedicine. 2018 Jun.

 Partial Intrinsic Disorder Governs the Dengue Capsid Protein Conformational Ensemble

Boon PL, Saw WG, Lim XX, Raghuvamsi PV, Huber RG, Marzinek JK, Holdbrook DA, Anand GS, Grüber G, Bond PJ. 

ACS Chemical Biology. 2018 May 24;13(6):1621-30.

2017

Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface

Lim XX, Chandramohan A, Lim XY, Crowe Jr JE, Lok SM, Anand GS.

Structure. 2017 Sep 5;25(9):1391-402.

 Channeling of cAMP in PDE-PKA complexes promotes signal adaptation

Tulsian NK, Krishnamurthy S, Anand GS.

Biophysical Journal. 2017 Jun 20;112(12):2552-66.

Dissecting Orthosteric Contacts for a Reverse-Fragment-Based Ligand Design

Chandramohan A, Tulsian NK, Anand GS. 

Analytical Chemistry. 2017 Jul 14;89(15):7876-85.

Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays

Ghosh M, Wang LC, Ramesh R, Morgan LK, Kenney LJ, Anand GS.

Biophysical Journal. 2017 Feb 28;112(4):643-54.

Conformational changes in intact dengue virus reveal serotype-specific expansion

Lim XX, Chandramohan A, Lim XY, Bag N, Sharma KK, Wirawan M, Wohland T, Lok SM, Anand GS.

Nature Communications. 2017 Feb 10;8:14339.

2016

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase

Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR.

Scientific Reports. 2016;6.

Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions

Husain N, Tulsian NK, Wang LC, Anand GS, Sivaraman J. 

Scientific Reports. 2016;6. 

Predicting allosteric effects from orthosteric binding in Hsp90-ligand interactions: Implications for Fragment-based drug design

Chandramohan A, Krishnamurthy S, Larsson A, Nordlund P, Jansson A, Anand GS.

PLoS Computational Biology. 2016 Jun 2;12(6):e1004840.

2015

Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling

Krishnamurthy S, Tulsian NK, Chandramohan A, Anand GS.

Biophysical Journal. 2015 Sep 15;109(6):1251-63.

2014

Active site coupling in PDE: PKA complexes promotes resetting of mammalian cAMP signaling

Krishnamurthy S, Moorthy BS, Lim XX, Lim XS, Bharatham K, Tulsian NK, Mihalek I, Anand GS. 

Biophysical Journal. 2014 Sep 16;107(6):1426-40.

Distinguishing direct binding interactions from allosteric effects in the protease–HK97 prohead I δ domain complex by amide H/D exchange mass spectrometry.

Krishnamurthy S, Veesler D, Khayat R, Snijder J, Huang R, Heck AJ, Johnson J, Anand GS.

Bacteriophage. 2014 Dec 15;4(4):e959816.

Architecture of a dsDNA viral capsid in complex with its maturation protease

Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE.

Structure. 2014 Feb 4;22(2):230-7. 

2013

Dynamics of phosphodiesterase-induced cAMP dissociation from protein kinase A: capturing transient ternary complexes by HDXMS

Krishnamurthy S, Moorthy BS, Liqin L, Anand GS.

Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics. 2013 Jun 30;1834(6):1215-21.

2012

The inner membrane histidine kinase EnvZ senses osmolality via helix‐coil transitions in the cytoplasm

Wang LC, Morgan LK, Godakumbura P, Kenney LJ, Anand GS.

The EMBO Journal. 2012 May 30;31(11):2648-59.

Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases

Nambi S, Badireddy S, Visweswariah SS, Anand GS.

Journal of Biological Chemistry. 2012 May 25;287(22):18115-29.

Multistate allostery in response regulators: phosphorylation and mutagenesis activate RegA via alternate modes

Moorthy BS, Anand GS.

Journal of Molecular Biology. 2012 Apr 13;417(5):468-87.

2011

Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design

Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor SS, Qingsong L, Swaminathan K, Anand GS. 

Molecular & Cellular Proteomics. 2011 Mar 1;10(3):M110-004390.

Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination

Moorthy BS, Gao Y, Anand GS.

Molecular & Cellular Proteomics. 2011 Feb 1;10(2):M110-002295.

2010

Cyclic AMP-and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RIα) subunits of cyclic AMP-dependent protein kinase

Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA.

Molecular & Cellular Proteomics. 2010 Oct 1;9(10):2225-37.

2009

Structural basis for the inhibition mechanism of human cystathionine γ-lyase, an enzyme responsible for the production of H2S. Journal of Biological Chemistry

Sun Q, Collins R, Huang S, Holmberg-Schiavone L, Anand GS, Tan CH, Van-Den-Berg S, Deng LW, Moore PK, Karlberg T, Sivaraman J.

Journal of Biological Chemistry. 2009 Jan 30;284(5):3076-85.

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