Anand Lab
Conformational dynamics of macromolecular assemblies by structural mass spectrometry: from proteins to virus particles
Research
Protein dynamics is central to biological function. Our group’s research interests are in probing protein dynamics in cell signaling with a focus on allostery, conformational dynamics of viral capsids, transmembrane receptor signaling, and targeted drug discovery.
Protein dynamics is probed by multiple biophysical tools including amide hydrogen/deuterium exchange mass spectrometry (HDX-MS), native mass spectrometry, and limited proteolysis-mass spectrometry (LiP-MS). Our goal is to integrate protein dynamics with structural tools for describing biological function.
Our Research Focus
Our research focuses on probing protein dynamics to map biomolecular interactions and allostery in cell signaling pathways and viruses
Research Techniques
We combine biophysical techniques with biochemical tools to probe protein dynamics
Interested in Joining the Lab?
Interested graduate and undergraduate students are welcome to join us! Click the link below to learn more.